Targeted Drug Delivery / Smart Drug Delivery / Drug Targeting
Fariba Ourang; Mohammad Rafienia
Volume -1, Issue 2 , June 2005, , Pages 173-179
Abstract
Polyurethane micro spheres have been synthesized by solvent evaporation technique with castor oil, Polycaprolacton (PCL), Hexamethylen diisocyanate (HMDI) and Ethyl diamine (ED) as carriers for controlled drug delivery systems. Release behavior of micro spheres has been investigated using Bromocresol ...
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Polyurethane micro spheres have been synthesized by solvent evaporation technique with castor oil, Polycaprolacton (PCL), Hexamethylen diisocyanate (HMDI) and Ethyl diamine (ED) as carriers for controlled drug delivery systems. Release behavior of micro spheres has been investigated using Bromocresol purple die. Fourier transmission infrared (FTIR), Scanning Electron Microscope (SEM), Optical microscope, dissolution instrument and UV spectrophotometer were used to investigate the polymerization process, surface morphology, particle size, rate of release and calibration curve respectively. Results showed that urethane bonds were formed at 3300-3400cm-1 and 1650-1700 cm-1. SEM micrographs showed surface irregularities as a result of solvent evaporation. Particle sizes were higher for castor oil/HMDI rather than PCL/HMDI microbe ads and in both cases, particle size and Bromocresol purple die release increased with rising NCO/OH ratio.
Tissue Engineering
Karim Asgarzadeh Tabrizi; Fariba Ourang
Volume -1, Issue 1 , June 2004, , Pages 57-64
Abstract
Gelatin is a protein which is derived from the organic constituent of bone (collagen). Combination of this protein with the inorganic constituent of bone (hydroxyapatite) may provide closer properties to the natural bone. In this study, a biodegradable composite scaffold based on gelatin and hydroxyapatite ...
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Gelatin is a protein which is derived from the organic constituent of bone (collagen). Combination of this protein with the inorganic constituent of bone (hydroxyapatite) may provide closer properties to the natural bone. In this study, a biodegradable composite scaffold based on gelatin and hydroxyapatite was prepared as a substitute for bone tissue. To increase the biocompatibility of this, composite, its fabrication was carried out without using any organic solvent. Porosities obtained were spontaneously achieved without any porogen. The pore morphology indicated a high interconnectivity with diameters ranging from 50 to 200 micrometers, which seems appropriate for bone tissue engineering applications. In order to study the biocompatibility of the scaffolds, mouse fibroblastic cells were used. After 24-hour cell culture period in vitro, suitable cell attachment was observed showing high biocompatibility for all the samples. Further examinations demonstrated that the best biocompatibility is obtained for the composite of 50 wt% hydroxyapatite and 50 wt% gelatin.
